Biomarkers in overactive bladder : Where do we stand today ?

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Recent Investigations of Urinary Nerve Growth Factor as a Biomarker for Overactive Bladder Syndrome

Purpose: Overactive bladder (OAB) is a symptom syndrome and is usually diagnosed by subjective symptoms of urgency with or without urgency incontinence. However, because urgency symptoms are so subjective, it is difficult to objectively grade symptoms of urgency. Although urodynamic study can detect detrusor overactivity (DO) objectively, not all patients with OAB are found to have DO. Therefor...

The Effect of Electrical Nerve Stimulation in Management of Overactive Bladder in the Pediatric Population; A Systematic Review and Meta-Analysis

Background: In traditional medicine and recent years, nerve stimulation has been introduced as a replacement therapy for managing several disorders such as overactive bladder. However, there is still controversy in this regard. Therefore, the present meta-analysis aimed to assess the effectiveness of electrical nerve stimulation in treatment of overactive bladder.Methods: The present systematic...

Stand up urgency: is this symptom related to a urethral mechanism?

OBJECTIVE To study the role of women's position as a stimulus of urgency, and specifically the change of position, i.e. to stand up form a lying or sitting position. Thus, we compared clinical and urodynamics characteristics among women with overactive bladder syndrome (OAB) depending of the position which could trigger urgency. METHODS Thirty-eight females with complaints of urgency, without...

Biomarkers in Overactive Bladder: A New Objective and Noninvasive Tool?

Overactive bladder syndrome (OAB) is a highly prevalent urinary dysfunction, with considerable economic and human costs. Clinical diagnosis of OAB is still based on subjective symptoms. A new accurate, objective and noninvasive test to diagnose OAB and assess therapeutic outcome is lacking. Recent studies in lower urinary tract (LUT) dysfunctions, particularly in OAB patients, indicate that uri...